The Hematology Human iPSC Core at St. Jude Children’s Research Hospital offers a collaborative service to characterize and differentiate iPSC lines solely for the benefit of researchers engaged in pluripotent stem cell and hematopoiesis research. Our core routinely assists collaborators to differentiate hematopoietic progenitor cells from human iPSC and generate other blood lineages (e.g., myeloid, erythroid, megakaryocyte, monocytes) as their projects are needed. The core provides iPSC maintenance, characterization, distribution, and quality control services. Our core also provides hematopoietic disease modeling by generating iPSCs from patients or by using CRISPR-Cas9 gene editing to modify endogenous loci. Currently, the core has multiple hematopoietic disease models, such as bone marrow failure syndromes, sickle cell disease, Diamond-Blackfan anemia, and leukemia. The iPSC Core also offers training for investigators interested in learning how to work with iPSC in their own labs.
Contact:
Lei Han
Director, Hematology Human iPSC Core
St. Jude Children’s Research Hospital
901-595-5062
lei.han@stjude.org
