The Jackson Laboratory (JAX), Cellular Engineering Service
The Cellular Engineering Service at JAX is part of the Scientific Services which provides extensive resources and support to its research faculty and staff across JAX campuses in Maine, Connecticut, and California. The Cellular Engineering laboratory is physically located on the Farmington, Connecticut campus and is primarily dedicated to supporting extensive editing work with human stem cells. We use CRISPR/Cas strategies to create custom-edited cell lines with a range of allele types, including knockouts, single-base variants and conditional loss-of function alleles. In addition to work within JAX, our laboratory has external service contracts to carry out high-throughput hiPSC engineering for the iPSC Neurodegeneration Initiative (iNDI). This currently involves engineering a series of alleles in the well-characterized hiPSC line KOLF2.1. These cell lines undergo extensive quality control for genomic stability and pluripotency and will be distributed by JAX beginning in 2022. In addition to editing, we provide services such as iPSC differentiation, stem cell training, and project consultation.
For more information visit the JAX Scientific Services webpage at:
https://www.jax.org/research-and-faculty/research-overview/scientific-services
The Jackson Laboratory is an independent, nonprofit biomedical research institution. Our mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.
More information on The Jackson Laboratory can be found at:
http://www.jax.org
Justin McDonough, Ph.D.
Justin.Mcdonough@jax.org
Associate Director, Cellular Engineering
860-837-2402 t | 203-745-9918 m
